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Abfrage Programm/Institut/Gruppe PSP-Element Kontakt Anhang Verwendung Publikation

Parkin – a gene associated with Parkinson´s Disease – is regulating a NF-kB dependent antiapoptotic pathway


Titel Pressemitteilung:

Parkinson-Forschung: Parkin schützt Nervenzellen vor dem Zelltod

Parkinson Research: Parkin Protects Neurons from Cell Death

Apr 2013 IDG
Dr. Daniel Krappmann/ Prof. Dr. W. Wurst PDF
PR 2013-02-01
Core statement:

This finding establishes a cell type and context specific regulation of a signaling pathway leading to cell death by identifying the role of Parkin in linear ubiquitination of NF-κB essential modulator (NEMO) and consequently in the maintenance of mitochondrial integrity. Thus, Parkin is acting as a modulator to increase neuronal viability under stress.


Core statement Pressemitteilung:

Parkinson’s disease is characterized by massive death of neurons in the brain. Parkin, a protein associated with the disease, has a wide neuroprotective, pro-survival activity. Until recently, however, it was unclear how this protection is mediated. In a joint study, scientists of Ludwig-Maximilians-Universität München (LMU) and Helmholtz Zentrum München identified a critical signaling pathway for this neuroprotective function. Their findings have now been published in the journal ‘Molecular Cell’.

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