PuSH - Publikationsserver des Helmholtz Zentrums München

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Abfrage Programm/Institut/Gruppe PSP-Element Kontakt Anhang Verwendung Publikation
Titel:

miR-335 promotes mesendodermal lineage segregation and shapes a transcription factor gradient in the endoderm

 

Apr 2014 IDR
HDC
SAM
G-502300-001
Lickert PDF
PM DE: PDF
PM EN: PDF
Publikation
Core statement:

miR-335 targets endoderm specific transcription factors to establish a spatio-temporal gradient formation in the endoderm and to stabilize lineage decisions during mesendoderm formation

Titel:

Wnt/β-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse

 


Titel Pressemitteilung:

Insulin-bildende Betazellen aus Stammzellen: Wissenschaftler entschlüsseln

Insulin-Producing Beta Cells from Stem Cells: Scientists Decipher Early Molecular Mechanisms of Differentiation

Oct 2013 IDR
HDC
SAM
G-502300-001
Lickert PDF
PM DE: PDF
PM EN: PDF
PR 2014-01-01
Publikation
Publikation
Core statement:

Wnt/β-catenin signalling and posterior extra-embryonic endoderm is essential for gastrula organizer formation and patterning of the three principal germ layers


Core statement Pressemitteilung:

The Wnt/β-catenin signaling pathway and microRNA 335 are instrumental in helping form differentiated progenitor cells from stem cells. These are organized in germ layers and are thus the origin of different tissue types, including the pancreas and its insulin-producing beta cells. With these findings, Helmholtz Zentrum München scientists have discovered key molecular functions of stem cell differentiation which could be used for beta cell replacement therapy in diabetes. The results of the two studies were published in the renowned journal Development.

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