PuSH - Publikationsserver des Helmholtz Zentrums München

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Abfrage Programm/Institut/Gruppe PSP-Element Kontakt Anhang Verwendung Publikation
Titel:

A type I interferon transcriptional signature precedes autoimmunity in children genetically at-risk of type 1 diabetes.


Titel Pressemitteilung:

Typ-1-Diabetes: Molekulare Hinweise auf eine bevorstehende Krankheitsentstehung gefunden

Type 1 Diabetes: Molecular Evidence of Imminent Disease Development

Apr 2014 IDF
HDC
SAM
G-502100-001
Ziegler PDF
PM DE: PDF
PM EN: PDF
PR 2014-03-01
Publikation
Core statement:

The results of this study indicate that infections in early childhood cause a specific immune response which might lead to islet autoimmunity.

 


Core statement Pressemitteilung:

Diagnosis of type 1 diabetes is preceded by the appearance of pancreatic islet cell autoantibodies circulating in the blood. Scientists of Helmholtz Zentrum München, in cooperation with colleagues from the University of Cambridge, have now found a transient, significant increase in the expression of antiviral interferon (IFN) immune response genes shortly before the first appearance of autoantibodies in the blood of children. The IFN immune response is often associated with a recent respiratory infection – a new indication that diseases of the upper respiratory tract may also contribute to the development of type 1 diabetes.

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