PuSH - Publikationsserver des Helmholtz Zentrums München

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Abfrage Programm/Institut/Gruppe PSP-Element Kontakt Anhang Verwendung Publikation
Titel:

GAD autoantibody affinity in adult patients with latent autoimmune diabetes, the study participants of a GAD65 vaccination trial

 


Titel Pressemitteilung:

Typ-1-Diabetes bei Erwachsenen: Affinität der Antikörper ist entscheidend

Type 1 diabetes in adults: Antibody affinity is decisive

Apr 2014 IDF
HDC
SAM
G-502100-001
Ziegler PDF
PM DE: PDF
PM EN: PDF
PR 2014-03-01
Publikation
Core statement:

Intervention with GAD-alum in LADA patients had no effect on GAD autoantibody (GADA) affinity. The data suggest that patients with low GADA affinity have a prolonged preservation of residual beta-cell function.

 


Core statement Pressemitteilung:

Patients with LADA – a form of autoimmune type 1 diabetes in adulthood – can be distinguished from patients with non-autoimmune type 2 diabetes by means of the antibody reaction affinity to the enzyme glutamic acid decarboxylase (GAD). Scientists from the Helmholtz Zentrum München have reported in the journal 'Diabetes Care' that high-affinity GAD antibodies are found in patients who produce only a little of their own insulin and who will require insulin therapy after only a relatively short time.

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