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Abfrage Programm/Institut/Gruppe PSP-Element Kontakt Anhang Verwendung Publikation
Titel:
Titel Pressemitteilung:

Lernen vom Haifisch - Optimierung menschlicher Antikörper

Learning from sharks - optimization of human antibodies

Oct 2014 STB
SAM
G-503000-001
Sattler PDF
PM DE: PDF
PM EN: PDF
WB 2014-12-01
AR 2014-12-01
PR 2014-05-01
Publikation
Core statement:
Core statement Pressemitteilung:

Genetically engineered antibodies are deployed successfully in cancer diagnostics and therapy. Therapeutic antibodies against Alzheimer’s disease and multiple sclerosis are currently under development. An important criterion when designing suitable antibody fragments is their stability. Comparing the antibodies of sharks, which are very old from an evolutionary perspective, with those of humans, a team of researchers at the Technische Universitaet Muenchen (TUM) and the Helmholtz Zentrum Muenchen discovered stabilizing mechanisms that can also be applied to optimize custom-tailored antibodies in humans.

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