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Abfrage Programm/Institut/Gruppe PSP-Element Kontakt Anhang Verwendung Publikation
Titel:

Pollen-derived non-allergenic substances enhance Th2-induced IgE production in B cells.

Pollen-derived nonallergenic substances are critical components for ragweed-induced allergy

 


Titel Pressemitteilung:

Nicht-allergene Pollenbestandteile können Allergien verstärken – neuer Mechanismus über B-Zellen

The role of B cells in the enhancement of pollen allergy - reaction to non-allergenic compounds

Oct 2015 IAF
EH
G-505400-001
Dr. Sebastian Öder; Alessandrini PDF
PM DE: PDF
PM EN: PDF
PR 2015-08-01
AR 2015-11-01
WB 2015-12-01
Publikation
Publikation
Core statement:

Aqueous pollen extracts, the protein-free fraction of Amb-APE and the pollen-contained substance PPE1 specifically enhance IgE-production in Th2-primed B cells. Thus, pollen-derived non-allergenic substances might be responsible for B cell-dependent aggravation of IgE-mediated allergies.


Core statement Pressemitteilung:

Neuherberg, August 13, 2015. Scientists at Helmholtz Zentrum München and TU München discovered a new mechanism how non-allergenic pollen mediators can enhance allergic reactions. Especially the so-called B cells play a critical role in this process. The results were recently published in the Journal ‘Allergy’ and might lead to new approaches for therapies.

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