PuSH - Publikationsserver des Helmholtz Zentrums München

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Abfrage Programm/Institut/Gruppe PSP-Element Kontakt Anhang Verwendung Publikation
Titel:

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease


Titel Pressemitteilung:

Tricktherapie mit Schilddrüsenhormon: Die Leber bekommt ihr Fett weg

Smart drug clears fat from liver and blood

Oct 2016 IDO
HDC
SAM
G-502200-001
Dr. Timo Müller PDF
PM DE: PDF
PM EN: PDF
WB 2017-06-01
PR 2016-10-01
Publikation
Core statement:

A new biomolecule delivers thyroid hormone T3 selectively to the liver and improves cholestrol metabolism without adverse effects in off-target tissues like the heart and the bone.


Core statement Pressemitteilung:

Scientists of Helmholtz Zentrum München and Technical University of Munich have developed a ‘smart’ drug that safely clears the liver of fat and prevents blood vessels from clogging up. Similar to a trojan horse, the drug enters the liver with a trick: It uses the pancreatic hormone glucagon as vehicle to shuttle thyroid hormone T3 the live while keeping it away from other organs, thereby improving cholesterol and lipid metabolism while avoiding typical side effects of thyroid hormone.

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