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Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance.

Titel Pressemitteilung:

Eine einzige fettreiche Mahlzeit kann schon den Stoffwechsel beeinflussen

A single high-fat meal can already influence metabolism

Oct 2016 IEG
Prof. Dr. Martin Hrabě de Angelis PDF
PR 2017-02-01
WB 2017-06-01
Core statement:

BACKGROUND: Dietary intake of saturated fat is a likely contributor to nonalcoholic fatty liver disease (NAFLD) and insulin resistance, but the mechanisms that initiate these abnormalities in humans remain unclear. We examined the effects of a single oral saturated fat load on insulin sensitivity, hepatic glucose metabolism, and lipid metabolism in humans. Similarly, initiating mechanisms were examined after an equivalent challenge in mice. METHODS: Fourteen lean, healthy individuals randomly received either palm oil (PO) or vehicle (VCL). Hepatic metabolism was analyzed using in vivo 13C/31P/1H and ex vivo 2H magnetic resonance spectroscopy before and during hyperinsulinemic-euglycemic clamps with isotope dilution. Mice underwent identical clamp procedures and hepatic transcriptome analyses. RESULTS: PO administration decreased whole-body, hepatic, and adipose tissue insulin sensitivity by 25%, 15%, and 34%, respectively. Hepatic triglyceride and ATP content rose by 35% and 16%, respectively. Hepatic gluconeogenesis increased by 70%, and net glycogenolysis declined by 20%. Mouse transcriptomics revealed that PO differentially regulates predicted upstream regulators and pathways, including LPS, members of the TLR and PPAR families, NF-κB, and TNF-related weak inducer of apoptosis (TWEAK). CONCLUSION: Saturated fat ingestion rapidly increases hepatic lipid storage, energy metabolism, and insulin resistance. This is accompanied by regulation of hepatic gene expression and signaling that may contribute to development of NAFLD

Core statement Pressemitteilung:

Die weltweite Ausbreitung von Übergewicht, Fettleibigkeit und Typ-2-Diabetes wird häufig mit dem Verzehr gesättigter Fette in Verbindung gebracht. Wissenschaftler am Deutschen Diabetes-Zentrum (DDZ) und am Helmholtz Zentrum München haben herausgefunden, dass bereits die einmalige Aufnahme einer größeren Menge Palmöl die Empfindlichkeit des Körpers für Insulin verringert sowie vermehrte Fetteinlagerungen und Veränderungen im Energiestoffwechsel der Leber hervorruft. Die Studienergebnisse aus dem ‚Journal of Clinical Investigation‘ geben Aufschluss über früheste Veränderungen im Leberstoffwechsel, die langfristig zu Fettlebererkrankungen bei Übergewicht und Typ-2-Diabetes führen können.

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