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Abfrage Programm/Institut/Gruppe PSP-Element Kontakt Anhang Verwendung Publikation
Titel:

MLL2 conveys transcription-independent H3K4 trimethylation in oocytes

Apr 2018 ICB
SAM
G-554200-001
Colome Tatche, Maria PDF
PM DE: PDF
PM EN: PDF
Publikation
Core statement:

In this paper, we show that in the mouse oocyte histone 3 K4 trimethylation (H3K4me3) accumulates at intergenic regions, putative enhancers and silent H3K27me3-marked promoters in a transcription-independent manner, and we show that ablation of the gene Mll2 results in loss of transcription-independent H3K4me3 but has limited effects on transcription-coupled H3K4me3 or gene expression.

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