PuSH - Publikationsserver des Helmholtz Zentrums München

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Abfrage Programm/Institut/Gruppe PSP-Element Kontakt Anhang Verwendung Publikation
Titel:

SINGLE-CELL ANALYSIS Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics.


Titel Pressemitteilung:

Kompletter Zellatlas eines unsterblichen Plattwurms

A complete cell atlas and lineage tree of the immortal flatworm

Aug 2018 ICB
SAM
G-503800-001
Prof. Dr. Dr. Fabian Theis PDF
PM DE: PDF
PM EN: PDF
PR 2018-04-01
Publikation
Core statement:

Flatworms of the species Schmidtea mediterranea are immortal—adult animals contain a large pool of pluripotent stem cells that continuously differentiate to all adult cell types. Therefore, single-cell transcriptome profiling of adult animals should reveal mature and progenitor cells. By combining perturbation experiments, gene expression analysis, a computational method that predicts future cell states from the transcriptional changes, and a lineage reconstruction method, we placed all major cell types onto a single lineage tree that connects all cells to a single stem cell compartment. We characterize gene expression changes during differentiation and discover cell types important for regeneration. Our results demonstrate the importance of single-cell transcriptome analysis for mapping and reconstructing fundamental processes of developmental and regenerative biology at high resolution.


Core statement Pressemitteilung:

Von einer einzigen Stammzelle zur Vielzahl hochdifferenzierter Körperzellen: Wissenschaftlerinnen und Wissenschaftler haben in „Science“ den vollständigen zellulären Stammbaum eines ausgewachsenen Organismus publiziert. Entscheidend war der kombinierte Einsatz von RNA- und computerbasierten Technologien durch die Helmholtz-Kollegen vom Max-Delbrück-Centrum für Molekulare Medizin (MDC) und vom Helmholtz Zentrum München.

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