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Abfrage Programm/Institut/Gruppe PSP-Element Kontakt Anhang Verwendung Publikation
Titel:

Gain-of-function mutations in a member of the Src family kinases cause autoinflammatory bone disease in mice and humans

Sep 2019 IEG
HDC
SAM
G-500600-001
Hrabě de Angelis, Martin PDF
PM DE: PDF
PM EN: PDF
Publikation
Core statement:

A gain-of-function point mutation was identified in the Src family kinase (SFK) member FGR as causative for the autoinflammatory bone disease CRMO, suggesting specific SFK inhibitors as potential therapeutic options in the treatment of human CRMO.

 

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