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Abfrage Programm/Institut/Gruppe PSP-Element Kontakt Anhang Verwendung Publikation
Titel:

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure


Titel Pressemitteilung:

Internationale Studien fördern Verständnis der Blutdruckregulation

Oct 2011 IHG
SAM
G-500700-001
Gieger PDF
PM DE: PDF
PM EN: PDF
PR 2011-09-01
Publikation
Core statement:

Jacques Beckmann and colleagues show that carriers of duplications of the locus 16p11.2 have notably lower postnatal weight and BMI compared with a reference population. Each of the observed associated characteristics is opposite of those reported in carriers of deletions at this locus. Deletion of this same section has previously been associated with obesity, indicating a possible opposing causal link between being underweight and being obese. Extremes at either end of the weight scale pose important health risks. Although a number of genetic variants have been associated with obesity, little is known about the genetic basis of being underweight. The authors conclude that severe obesity and being underweight could have mirror aetiologies, possibly through contrasting effects on energy balance.

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