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Abfrage Programm/Institut/Gruppe PSP-Element Kontakt Anhang Verwendung Publikation
Titel:

A platelet-mediated system for shuttling blood-borne bacteria to CD8a+ dendritic cells depends on glycoprotein GPIb and complement C3

Apr 2012 VIRO-KVA
VIRO
EH
G-520100-001
Busch PDF
PM DE: PDF
PM EN: PDF
WB 2012-07-01
AR 2012-07-01
Publikation
Core statement:

Protective immunity mediated by antigen-specific CD8+ T cells requires initial priming of effective effector and memory T cells by dendritic cells; we identified a novel complement and platelet-dependent pathway through which bacteria are efficiently shuttled into dendritic cells in the spleen.

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