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Conformational flexibility of an essential RNA binding protein plays important roles for RNA binding

Oct 2014 STB
Sattler PDF WB 2014-12-01
Core statement:

The essential splicing factor U2AF65 adopts a range of unbound conformations that include a pre-formed RNA-bound domain arrangement for specific recognition of intron RNA.


The study demonstrates that an essential RNA binding protein adopts a range of inactive conformations that play an important role for RNA binding.


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