PuSH - Publication Server of Helmholtz Zentrum München

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Titel:

A new model for post-integration latency in macroglial cells to study HIV-1 reservoirs of the brain


Titel Pressemitteilung:

Neues Modell für HIV-Forschung in Gehirnzellen

New Model to study HIV latency in brain cells

Oct 2015 VIRO
EH
G-502700-001
Prof. Dr. Ruth Brack-Werner PDF PR 2015-06-01
Publication
Core statement:

We conclude that latent HIV-1 in macroglial reservoirs can be activated by selected LRAs. Identification of small molecules that suppress HIV-1 reactivation supports functional cure strategies. We propose using the HNSC model to develop novel strategies to enforce provirus quiescence in the brain.


Core statement Pressemitteilung:

Neuherberg, June 18, 2015. Over 35 million people worldwide are currently infected by HIV. Antiviral therapies can keep the virus from multiplying. However, no drug can cure infection so far, because various cell types continue to carry the virus in a latent, i.e. quiescent, state. Scientists of Helmholtz Zentrum München have now established a model for latent HIV infection of brain cells. The researchers used this model to identify various compounds that affect latency of the virus in the brain. This study was published in the journal AIDS.

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