PuSH - Publication Server of Helmholtz Zentrum München

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Titel:

Network plasticity of pluripotency transcription factors in embryonic stem cells.

Different than previously assumed: The dynamics of pluripotency transcription factors


 


Titel Pressemitteilung:

Anders als bisher gedacht: Die Dynamik von Pluripotenz-Transkriptionsfaktoren

Different than previously assumed: The dynamics of pluripotency transcription factors

Oct 2015 ISF
SAM
G-500800-001
Prof. Dr. Fabian Theis PDF WB 2015-12-01
PR 2015-09-01
Publication
Core statement:

The protein expression of the pluripotency factor Nanog fluctuates strongly in mouse embryonic stem cells and seems only weakly regulated.

We systematically analysed the kinetics of protein expression in mouse embryonic stem cells an discovered that variations in the Nanog expression are not necessarily linked to differences in the expression of other pluripotency factors.

 


Core statement Pressemitteilung:

Scientists at the Helmholtz Zentrum Munich working in collaboration with colleagues at ETH Zurich have discovered that variations in the Nanog expression of embryonic stem cells are not necessarily linked to differences in the expression of other pluripotency factors. The results of the study, which has now been published in the scientific journal Nature Cell Biology, refute previously held assumptions.

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