PuSH - Publication Server of Helmholtz Zentrum München

1 Records found.
▮◀ ◀◀ [[[loop pages]]] ... [[[pool pages]]] ▶▶ ▶▮
Query Programme/Institute/Group PSP element Contact Attachment Usage Publication

elF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.


Oct 2015 IEG
Hrabe de Angelis PDF Publication
Core statement:

The observation that elF6 depletion leads to a specific transcriptional signature in insulin-responsive tissues, induces Fasn reduction and histone acetylation and the fact that obesity, type 2 diabetes, and cancer require a Fasn-driven lipogenic state, turned elF6 driven translation to a potential therapeutic target for these diseases in the future.


▮◀ ◀◀ [[[loop pages]]] ... [[[pool pages]]] ▶▶ ▶▮