PuSH - Publication Server of Helmholtz Zentrum München

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Query Programme/Institute/Group PSP element Contact Attachment Usage Publication
Titel:

elF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.

 

Oct 2015 IEG
HDC
SAM
G-500600-001
Hrabe de Angelis PDF Publication
Core statement:

The observation that elF6 depletion leads to a specific transcriptional signature in insulin-responsive tissues, induces Fasn reduction and histone acetylation and the fact that obesity, type 2 diabetes, and cancer require a Fasn-driven lipogenic state, turned elF6 driven translation to a potential therapeutic target for these diseases in the future.

 

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