PuSH - Publication Server of Helmholtz Zentrum München

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Hypothalamic Leptin Action is Mediated by Histone Deacetylase 5

Titel Pressemitteilung:

Helmholtz-Wissenschaftler entdecken neuen Schalter für das Sättigungsgefühl

Helmholtz Researchers Identify Genetic Switch Regulating Satiety and Body Weight

Oct 2016 IDO
Tschöp PDF PR 2016-02-01
Core statement:

Histone deacetylases (HDACs) regulate energy metabolism in peripheral tissues, but whether HDACs expressed in the brain influence systemic metabolism is unknown. Here, Researchers at the research unit NeuroBiology of Diabetes and the Institute for Diabetes and Obesity show that hypothalamic HDAC5 expression is affected by the diet and HDAC5 regulates leptin sensitivity by deacetylating STAT3.

Core statement Pressemitteilung:

A team of researchers at Helmholtz Zentrum München, Technische Universität München and the German Center for Diabetes Research (DZD) has identified a new mechanism that regulates the effect of the satiety hormone leptin. The study published in the journal ‘Nature Communications’ identified the enzyme HDAC5 as key factor in our control of body weight and food intake and potential target against the Yoyo dieting effect.

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